论文部分内容阅读
目的具有高亲和力和高选择性丹参酮IIA(TSIIA)分子印记聚合物(MIPs)的制备及其机制研究。方法以丹参酮IIA为模板分子,通过对硅胶表面进行接枝共聚,合成了基于硅胶表面修饰的MIPs。通过量子化学的方法对模板分子与功能单体的结合构象进行了计算机模拟,紫外吸收光谱法研究印记机制。结果模板分子与功能单体间理论最佳物质的量比为1∶3,甲基丙烯酸(MAA)比丙烯酰胺(AAM)更适合合成MIPs。结论该MIPs可用于TSIIA的提取分离。
Objective To study the preparation and mechanism of tanshinone IIA (TSIIA) molecularly imprinted polymers (MIPs) with high affinity and selectivity. Methods Tanshinone IIA was used as a template to synthesize MIPs based on the surface modification of silica gel by graft copolymerization on the surface of silica gel. Through the quantum chemistry method, the binding conformation of the template molecule and the functional monomer was simulated by computer. The mechanism of imprinting was studied by UV absorption spectroscopy. Results The molar ratio of template to functional monomer was 1: 3, and MAA was more suitable than synthetic acrylamide for the synthesis of MIPs. Conclusion The MIPs can be used for TSIIA extraction and separation.