患者男，农民，47岁。自幼手指粗大，于1996年4月1日来院就诊。该患者2岁时因感冒在当地医院发现“心脏有杂音”。患者家族史不详，4岁时其母去世，病因不详。查体：发育正常（除手指畸形外），智力正常，听诊心尖部第一心音亢进，并可闻及隆隆样舒张期杂音。足趾发育正常。双侧 Male patient, farmer, 47 years old. Since childhood, fingers coarse, came to hospital on April 1, 1996. The patient was found to have a “heart murmur” at a local hospital due to a cold at 2 years of age. The patient’s family history is unknown, his mother died at the age of 4, the cause is unknown. Physical examination: normal development (except finger deformity), normal intelligence, auscultation apex heart sound hyperthyroidism, and can be heard and rumbling like diastolic murmur. Toe development is normal. Bilateral