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为探讨膀胱移行细胞癌组织中肿瘤微血管不同类型与浸润和转移的关系，应用免疫组织化学ＳＰ法在６１例膀胱移行细胞癌组织中对第Ⅷ因子相关抗原进行表达并计数，根据肿瘤组织中微血管（ＭＶ）的分布特点及其与肿瘤组织的关系，将ＭＶ分为两型：Ⅰ型为肿瘤组织内ＭＶ，位于癌组织内，血管迂曲，扩张，变形；Ⅱ型为肿瘤旁ＭＶ，位于肿瘤边缘，血管分布不均。结果显示浸润性癌组的Ⅱ型ＭＶ数显著高于Ⅰ型ＭＶ数（Ｐ＜００５），在浅表性癌组中Ⅰ，Ⅱ型ＭＶ数之间无显著性差异（Ｐ＞００５），伴淋巴结转移的癌组织Ⅱ型ＭＶ数显著高于Ⅰ型ＭＶ数（Ｐ＜００５）。认为肿瘤血管的生长有很大的异质性，肿瘤边缘的微血管与肿瘤的浸润有密切关系。
To investigate the relationship between different types of tumor microvessels and infiltration and metastasis in bladder transitional cell carcinoma, immunohistochemical SP method was used to express and count VIII factor-related antigen in 61 cases of bladder transitional cell carcinoma, according to the microvessels in the tumor tissue. (MV) distribution characteristics and its relationship with tumor tissue, MV is divided into two types: type I is the MV in the tumor tissue, located in the cancer tissue, vascular distortion, expansion, deformation; type II is the tumor around the MV, located in the tumor Edges, blood vessels are unevenly distributed. The results showed that the number of type II MV in invasive carcinoma was significantly higher than that of type I (P<005). There was no significant difference in the number of type I and type II MV in the superficial carcinoma (P>0). 05) The number of type II MVs in cancerous tissues with lymph node metastasis was significantly higher than that in type I MVs (P < 0.05). It is believed that there is a great deal of heterogeneity in the growth of tumor blood vessels, and the microvasculature at the edge of the tumor is closely related to the infiltration of tumors.