美国一位糖尿病专家指出,非胰岛素依赖性糖尿病(NIDDM)的不同基因机制决定了β细胞功能不全的各种表现。芝加哥大学糖尿病研究小组主任、医学教授Kenneth Polonsky,在β细胞对NIDDM的作用方面有许多新的发现。在最近举行的美国糖尿病协会年会上,他提出了一篇很重要的论文。葡糖激酶的突变与称作“青年成熟发作型糖尿病”(MODY)的NIDDM早期发作综合征有关。在葡萄糖代谢过程中,葡糖激酶是速率 A US diabetes expert points out that the different genetic mechanisms of non-insulin-dependent diabetes mellitus (NIDDM) determine various manifestations of beta-cell dysfunction. Kenneth Polonsky, a professor of medicine at the University of Chicago’s Diabetes Research Group, has many new discoveries in the role of beta cells in NIDDM. At the recent annual meeting of the American Diabetes Association, he presented a very important essay. Mutations in glucokinase are associated with early episodes of NIDDM called “young mature onset diabetes mellitus” (MODY). Glucokinase is the rate during glucose metabolism