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目的探讨老年高血压患者的动态脉压(PP)与冠心病并发症及颈动脉粥样硬化之间的关系。方法选取2006年12月～2012年1月间于某院门诊或住院治疗的老年高血压患者341例,其中合并冠心病的165例病例为A组,单纯的老年高血压患者176例为B组,监控两组动态脉压,对比观察两组动态PP的差异;另对B组176例病例根据颈动脉内膜中层厚度(IMT),IMT≥0.9 mm为颈动脉内膜中层增厚组,共91例为α组,其余85例为β组,比较两组动态PP的差异。结果合并冠心病组和颈动脉内膜中层增厚组的24 h APP、dPP、nPP水平明显高于单纯高血压组和颈动脉内膜中层厚度正常组。结论动态脉压水平对冠心病并发症和颈动脉粥样硬化病变有提示作用,动态脉压越高,冠心病并发症和颈动脉粥样硬化病变发病率越高。
Objective To investigate the relationship between dynamic pulse pressure (PP) and coronary artery disease and carotid atherosclerosis in elderly patients with hypertension. Methods A total of 341 elderly hypertensive patients undergoing outpatient or inpatient treatment from December 2006 to January 2012 were enrolled. Among them, 165 patients with coronary heart disease were Group A, 176 patients with simple hypertension were Group B , The two groups of dynamic pulse pressure were monitored to compare the difference of dynamic PP between the two groups; the other 176 cases of group B were divided into carotid intima-media thickness (IMT) and IMT≥0.9 mm 91 cases of α group, and the remaining 85 cases of β group, comparing the difference between the two groups of dynamic PP. Results The levels of APP, dPP and nPP at 24 h in patients with coronary heart disease and carotid intima-media thickness group were significantly higher than those in patients with hypertension and carotid intima-media thickness group. Conclusions The dynamic pulse pressure level has a significant effect on the complication of coronary heart disease and carotid atherosclerosis. The higher the dynamic pulse pressure, the higher the incidence of coronary heart disease and carotid atherosclerosis.