自从1962年发现萘啶酸以来,已经合成了很多类似物,最近合成的氟呱酸、氟啶酸、环丙氟呱酸等被认为是抗菌谱更广、抗菌作用更强的新一代吡酮酸抗菌剂。1984年,Wentland等根据生物电子等排体原理,合成了1—位氨基取代的一类新的吡酮酸衍生物,并证明CH_3NH~-取代的抗菌效果与氟呱酸相似。 Since nalidixic acid was discovered in 1962, many analogues have been synthesized. Recently, the new synthetic pyrazole, fubicidin and cyproterone derivatives have been considered as a new generation of pyrazolone which has a broader antibacterial spectrum and stronger antibacterial activity Acid antibacterial agent. In 1984, Wentland et al. Synthesized a class of novel pyrazolonic acid derivatives substituted by 1-amino group according to the principle of bioisostere and found that the antibacterial effect of CH 3 -NH ~ - substitution was similar to that of fleconimic acid.