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目的 探讨增殖细胞核抗原 (PCNA)的表达和DNA含量对喉癌临床生物学特征及预后的关系。方法 用免疫组化SP方法和自动图像分析仪检测正常喉粘膜、喉鳞癌的PCNA和DNA指数 (DI) ,结合临床随访资料进行分析。结果 喉鳞癌PCNA的阳性表达率为 10 0 % ,与正常喉组织有显著差异 (P <0 0 1) ,PCNA阳性表达强度和DNA指数随肿瘤分化程度的降低而相应增高 (P<0 0 5 )。两指标较高者生存时间较短 ,预后较差 (P <0 0 5 )。结论 PCNA的表达和DNA指数可为判断肿瘤的恶性程度及临床预后提供参考依据
Objective To investigate the relationship between the expression of proliferating cell nuclear antigen (PCNA) and DNA content in clinical biology and prognosis of laryngeal carcinoma. Methods The PCNA and DNA index (DI) of normal laryngeal mucosa and laryngeal squamous cell carcinoma were detected by immunohistochemical SP method and automatic image analyzer, and analyzed with clinical follow-up data. Results The positive rate of PCNA in LSCC was 100%, which was significantly different from that in normal laryngeal tissues (P <0.01). The positive expression of PCNA and DNA index increased with the decrease of tumor differentiation (P <0 0) 5). The two indicators of higher survival time is shorter, the prognosis is poor (P <0 05). Conclusions The expression of PCNA and DNA index may provide a reference for judging the malignant degree and clinical prognosis of the tumor