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何杰金氏病相关的T细胞急淋白血病(ALL)(2例)和B细胞ALL(1例)曾有报道,而合并普通型ALL系罕见的首次报道病例。患者男性,17岁,因何杰金氏病ⅡE期、结节硬化型于1984年4月入院。两肺纵膈及颈部淋巴结受累。经COPP方案(每疗程包含环磷酰胺600mg/m~2×2.长春新碱2mg,甲基苄肼100mg/m~2×14、强的松60mg×14)10个疗程,未行放疗,患者反应良好。化疗后5年出现疲乏、发热、衰弱等症状。血红蛋白6.3g/dl,白细胞3.3×10~9/L,原始淋巴细胞36%,成熟淋巴细胞63%,血小板4×10~9/L。骨髓原始细胞96%,此类细胞糖原、酸性磷酸酶、α-萘酚酯酶、过氧化物酶染色等均阴性。单克隆抗体免疫分型示CD-19、CD-9、CD-7及CD-10,分别有97%、77%、75%及67%的细胞阳性;HLA-DR和末端脱氧核苷酸转移酶(TdT)96%细胞阳性,诊断为前B型ALL(普通
Hodgkin’s disease-related T cell acute lymphoblastic leukemia (ALL) (2 cases) and B cell ALL (1 case) have been reported, and the common cases of ALL rare cases first reported cases. Male patient, 17 years old, Hodgkin’s disease stage IIE, nodular sclerosis in April 1984 admitted. Both lung mediastinal and cervical lymph nodes involved. The COPP program (each course contains cyclophosphamide 600mg / m ~ 2 × 2. Vincristine 2mg, procarbazine 100mg / m ~ 2 × 14, prednisone 60mg × 14) 10 courses, without radiotherapy, The patient responded well. 5 years after chemotherapy, fatigue, fever, weakness and other symptoms. 6.3g / dl of hemoglobin, 3.3x10-9 / L of leukocytes, 36% of primitive lymphocytes, 63% of mature lymphocytes and 4x10-9 / L of platelets. Bone marrow primitive cells 96%, such cells glycogen, acid phosphatase, α-naphthol esterase, peroxidase staining, etc. were negative. The monoclonal antibody immunophenotypes showed 97%, 77%, 75% and 67% positive for CD-19, CD-9, CD-7 and CD-10 respectively. HLA-DR and terminal deoxynucleotidyl transferase 96% of TdT positive cells were diagnosed as pre-B type ALL (normal