论文部分内容阅读
目的:分析辽宁省流行性脑脊髓膜炎(流脑)菌群分布和流行特征。方法:收集流脑病例,对流脑病例的脑脊液和血液进行增菌后分离培养、鉴定,密切接触者咽拭子标本,按照国标(GB16884-1997)方法进行培养、鉴定;双份血清检测采用ELISA方法。结果:从病例中分离到8株流脑菌,A群6株,占75%,B群2株,占25%;11例抗体呈4倍增高,A群5例,占45.5%,C群6例,占54.5%。从密切接触者中分离到流脑菌40株:A群29株,占72.5%;B群1株,占2.5%;C群4株,占10.0%;W135群1株,占2.5%;未定型5株,占12.5%。而流脑的发病数大幅下降后,以1～7岁组下降明显,大年龄组发病比例增加。结论:我省流脑仍以A群为优势菌群,但2004年以后出现C群病例,且流脑发病年龄后移,应密切注意C群流脑扩散趋势,加强流脑病原学监测,采取相应措施,控制流脑病例发生。
Objective: To analyze the distribution and epidemic characteristics of epidemic cerebrospinal meningitis in Liaoning Province. Methods: Cerebrospinal fluid (CSF) and blood samples were collected after enrichment of cerebrospinal fluid (CSF) and blood in meningioma cases. Throat swab specimens were identified and closely contacted. The samples were cultured and identified according to the national standard (GB16884-1997) method. Results: Eight strains of meningococci were isolated from the patients, including 6 strains of A group, accounting for 75% and 2 strains of B group, accounting for 25%. 11 cases showed a 4-fold increase in antibody, 5 cases in group A, accounting for 45.5% 6 cases, accounting for 54.5%. Forty meningococcal strains were isolated from close contacts: 29 strains of A group (72.5%), 1 strain of B group (2.5%), 4 strains of C group (10.0%), 1 strain of W135 (2.5%), undetermined 5 strains, accounting for 12.5%. The incidence of meningitis dropped significantly after the group of 1 to 7 years decreased significantly, the incidence increased in the older age group. Conclusion: A group of meningitis is still the predominant flora in meningoencephalitis. However, after 2004, there are cases of group C, and the age of meningitis is backward. We should pay close attention to the tendency of meningitis in group C and strengthen the surveillance of meningococcal disease. Corresponding measures to control the occurrence of meningitis cases.