亚急性硬化性全脑炎(SSPE)是由麻疹病毒持续感染引起的一种儿童和青年慢性进行性中枢神经系统疾病。麻疹病毒含有L、P、NP、H、F和M6种主要蛋白,其中M蛋白是在装配病毒起主要作用的膜内蛋白。在SSPE患者血清和脑脊液中麻疹病毒的其他蛋白抗体滴度很高,而M蛋白抗体相对缺少。M蛋白抗体缺少的原因可能是脑细胞内M蛋白合成减少。SSPE患者脑细胞经体外移植培养时,只有麻疹病毒 Subacute sclerosing panencephalitis (SSPE) is a chronic progressive central nervous system disorder in children and adolescents caused by the persistent infection with measles virus. The measles virus contains L, P, NP, H, F, and M6 major proteins, of which M protein is the major intramembrane protein responsible for assembly of the virus. The other antibodies to measles virus in the serum and cerebrospinal fluid of patients with SSPE have high titers of antibodies, while M protein antibodies are relatively absent. The reason for the lack of M protein antibody may be a decrease in M ​​protein synthesis in brain cells. SSPE patients with brain cells transplanted in vitro, only the measles virus