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由于HPA(人类血小板抗原)-1的多态性使母婴之间HPA-1不合,于是新生儿产生严重的新生儿同种免疫性血小板减少(NAITP)。估计在高加索人群中,发病率为1/1000,死亡率为10—20％。方法:回顾1995年6月到1998年5月的实验室记录,确定纳入和确诊的NAITP患儿的比率,临床资料查阅医院记录。结果:在这期间,8个家庭中有8例婴儿诊断为NAITP。另外,为调查以前的患儿涉及到2个妇女,本组还包括1998年5月以来4例病例,其中2例已知系抗—HPA—1a抗体影响了妊娠。87％的婴儿出生就有严重的血小板减少症—血小板<50×109/L。3个患儿的母亲有患病儿历史。所有病例均系HPA—1b母亲被HPA—1a同种免疫所致。4个患儿是第一胎,所有病例都是正常妊娠。81％(13例)是自然分娩,分娩时62.5％(10
Due to HPA (human platelet antigen) -1 polymorphisms between maternal and neonatal HPA-1, then neonatal severe neonatal alloimmune thrombocytopenia (NAITP). It is estimated that in Caucasians, the incidence is 1/1000 and the mortality rate is 10-20%. METHODS: A review of laboratory records from June 1995 to May 1998 was conducted to determine the percentage of children with NAITP who were included and confirmed, and clinical data were reviewed for hospital records. Results: During this period, 8 infants in 8 families were diagnosed with NAITP. In addition, in order to investigate the two previous women involved in the treatment of children, this group also includes four cases since May 1998, two of which are known to affect anti-HPA-1a antibody pregnancy. 87% of babies born with severe thrombocytopenia - platelets <50 × 109 / L. Three children’s mothers have a history of sick children. All cases were induced by HPA-1a alloimmunization with HPA-1b mothers. 4 children are the first child, all cases are normal pregnancy. 81% (13 cases) were spontaneous deliveries and 62.5% at delivery (10%)