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流行病学调查已表明遗传因素在北方鼻咽癌的发病上起到一定作用,遗传度为72.95％±7.69％,且有家族聚集性。本文的目的是从鼻咽癌病人的染色体改变上探讨其遗传性,寻找鼻咽癌早期诊断的方法。材料和方法病例组15例是鼻咽癌初诊病人,未做过放疗和化疗。对照组5例是鼻咽部非肿瘤性疾病患者。两组人员均无特殊的职业接触史。病例组平均年龄为48.4岁,对照组平均年龄为36.4岁。采静脉血1.0-1.5ml,肝素抗凝。5 ml1640培养液(含20％小牛血清)加全血0.5ml,常规培养72小时。收获前2小时加秋水仙素
Epidemiological studies have shown that genetic factors play a role in the pathogenesis of nasopharyngeal carcinoma in the North, the heritability is 72.95% ± 7.69%, and there is familial aggregation. The purpose of this article is to explore the hereditary nature of the chromosome changes in patients with nasopharyngeal carcinoma, looking for early diagnosis of nasopharyngeal carcinoma. Materials and Methods Case group of 15 cases of nasopharyngeal carcinoma patients newly diagnosed, not done radiotherapy and chemotherapy. The control group of 5 patients with nasopharyngeal non-neoplastic disease. There was no special history of occupational exposure between the two groups. The average age of the case group was 48.4 years and the mean age of the control group was 36.4 years. Venous blood 1.0-1.5ml, heparin anticoagulation. 5 ml1640 culture medium (containing 20% bovine serum) plus whole blood 0.5ml, routine culture for 72 hours. Add colchicine 2 hours before harvest