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By investigating the effect of the amount of water, the ratio of aldehyde and allylbromide, and the reaction temperature on the transformation, 2,4,6-trisubstituted tetrahydropyrans are synthesized by a novel tandem Barbier-Prins-cyclization reaction in the presence of micro-amount of water under mild conditions. The experiment is easy to perform without the need to exclude moisture or air. The reaction is atomic economical and environmentally benign.