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本文用PCR及内切酶消化方法把ⅡE1分成三种基因型，即A型为C1基因的纯合子，B型为C1和C2基因的杂合子，C型为C2基因的合子。结果表明，在70例非酒精性肝病中，A、B、C型分别为62．8％、35．7％及1．4％，与正常人群比较无差异。酒精性肝病与正常对照组及非酒精性肝病比较，A型明显降低（P＜0．01），B型明显增高（P＜0．01）。与非酒精相关的肝癌比较，洒精相关性肝癌的A型也明显减少，而B型则明显增多。提示C2基因在形成酒精性肝病及导致酒精相关性肝癌中起着一定的作用。
In this paper, ⅡE1 is divided into three genotypes by PCR and endonuclease digestion, that is, type A is a homozygote of C1 gene, type B is a heterozygote of C1 and C2 genes, and type C is a zygote of C2 gene. The results showed that in 70 cases of non-alcoholic liver disease, A, B, C type were 62.8%, 35.7% and 1.4%, no difference compared with the normal population. Compared with normal control group and non-alcoholic liver disease, alcoholic liver disease showed that type A decreased significantly (P <0.01) and type B increased significantly (P <0.01). Compared with non-alcohol-related liver cancer, A-type associated with HCC-related hepatocellular carcinoma was significantly reduced, while B-type was significantly increased. Suggesting that C2 gene plays a role in the formation of alcoholic liver disease and alcohol-related liver cancer.