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前列腺癌是欧美发达国家继肺癌之后男性患者第二多的恶性肿瘤,病死率在肺支气管癌、肝癌、胃癌、结直肠癌、食管癌之后位列第六[1]。在我国占男性泌尿系肿瘤第三位,有逐年上升的趋势。直肠指检、经直肠B超检查(TRUS)[2]和血清前列腺特异性抗原(PSA)测定[3]是临床诊断前列腺癌的基本方法。前列腺癌的潜在危险因素包括年龄、种族、遗传、饮食高动物脂肪、环境工业在市区的污染、吸烟、输精管切除术等。上个世纪40年代初,Huggins和Hodges发现了通过切除前列腺癌患者双侧睾丸和运用雌激素可延缓前列腺癌的进展,证实了前列腺癌对雄激素去除的反应性[4]。患者体内无雄激素水平作用下,前
Prostate cancer is the second most common malignant tumor in male patients in developed countries in Europe and the United States following lung cancer. The case fatality rate ranks the sixth after bronchial cancer, liver cancer, gastric cancer, colorectal cancer and esophageal cancer [1]. In our country the third male urinary tract tumors, there is a trend of rising year by year. Rectal examination, transrectal ultrasound B (TRUS) [2] and serum prostate specific antigen (PSA) determination [3] are the basic methods of clinical diagnosis of prostate cancer. Potential risk factors for prostate cancer include age, ethnicity, heredity, high dietary fat, environmental industrial pollution in urban areas, smoking, vasectomy and more. In the early 1940s, Huggins and Hodges found that prostate cancer response to androgen ablation was confirmed by resection of both testicles in patients with prostate cancer and the use of estrogen to delay the progression of prostate cancer [4]. No effect of androgens in the body of the patient, before