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目的通过对心脏机械瓣膜置换术后患者抗凝治疗依从性的调查分析，寻找提高患者抗凝治疗依从性的方法，从而解决抗凝治疗的有效性、安全性问题。方法选取我科2012年4月~2013年12月出院的心脏机械瓣膜置换术后患者220例，通过填写问卷调查的方法，收集总结影响抗凝治疗依从性的因素。结果通过调查，影响抗凝治疗依从性的因素主要有：患者的年龄、文化程度、职业及出院时间长短。结论针对影响因素进行分析，实施护理干预，提高患者的依从性，保证患者抗凝治疗安全有效。“,”Objective By means of anticoagulation therapy after mechanical heart valve replacement patients compliance investigation and analysis, look for ways to improve the anticoagulant treatment compliance of patients, so as to solve the problem of security and ef icacy of anticoagulation. Methods Our department in April 2012~December 2013 discharged patients after mechanical heart valve replacement 220 cases, by fil ing in questionnaires, the method of col ecting summarized the influencing factors of anticoagulant treatment adherence. Results Through survey, the major factors that af ect the anticoagulant treatment adherence are: patient's age, cultural degree, occupation and discharge time length. Conclusion In view of the influence factors were analyzed, and the implementation of nursing intervention, to improve patients compliance, ensure patient anticoagulant therapy is safe and ef ective.