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1引言尽管大量抗惊厥药是有效的，但是目前使用的这些药物不仅不能控制占病人比例很大的几种类型的癫病发作，而且经常引起不同程度甚至严重的副作用。对于这些化学上各不相同的抗惊厥药，人们已经提出了许多作用机理，但最新的知识表明它们基本上要么是通过阻断神经元高频率重
1 Introduction Although a large number of anticonvulsants are effective, the current use of these drugs not only fails to control several types of epileptic seizures that account for a large proportion of patients, but often causes varying degrees and even serious side effects. Many mechanisms of action have been proposed for these chemically different anticonvulsants, but current knowledge suggests that they either essentially act by blocking neuronal firing at high frequencies