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目的:探讨埃索美拉唑联合莫沙比利治疗反流性食管炎的临床疗效和不良反应情况。方法:选取2013年9月至2015年9月收治的反流性食管炎患者78例,随机分为两组,各39例。对照组行奥美拉唑治疗,观察组行埃索美拉唑联合莫沙比利治疗,对比两组治疗有效率、治疗前后临床症状评分和不良反应情况。结果:观察组治疗有效率高于对照组,差异显著(P<0.05);观察组治疗4周、8周临床症状评分低于对照组,差异显著(P<0.05);观察组不良反应发生率与对照组相比,无明显差异(P>0.05)。结论:埃索美拉唑联合莫沙比利治疗反流性食管炎可明显提高疗效,减轻临床症状,且不良反应少,值得推广。
Objective: To investigate the clinical efficacy and adverse reactions of esomeprazole combined with mosapride in the treatment of reflux esophagitis. Methods: Seventy-eight patients with reflux esophagitis who were admitted from September 2013 to September 2015 were randomly divided into two groups (n = 39 in each group). The control group was given omeprazole, while the observation group was treated with esomeprazole combined with mosapride. The treatment efficiency, clinical symptom scores and adverse reactions before and after treatment were compared. Results: The effective rate of observation group was higher than that of control group (P <0.05). The score of clinical symptom of observation group was lower than that of control group at 4 weeks and 8 weeks (P <0.05), and the incidence of adverse reactions in observation group Compared with the control group, there was no significant difference (P> 0.05). Conclusion: Esomeprazole combined with mosapride in the treatment of reflux esophagitis can significantly improve the curative effect, reduce the clinical symptoms, and less adverse reactions, which is worth promoting.