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目的:研究中药蝙蝠葛的化学成分。方法:应用硅胶和凝胶反复柱层析进行分离,分得成分用波谱分析和理化性质对照进行结构鉴定。结果:分离鉴定出8种成分,分别为meniscoside(1),dauricoside(2),dauriporphine(3),menisporphine(4),bianfugecine(5),2,3-dihydromenisporphine(6),syringaresinol(7)和syringaresinol4,4′-O-bis-glucoside(8)。结论:化合物1为新的苄基异喹啉生物碱葡萄糖苷,首次报道化合物1-6在对多巴胺D1和D2受体竞争性结合实验中,表现出对D1受体明显的选择性结合,其中1和2的IC50分别为9.2和2.0μmol?L-1。
Objective: To study the chemical composition of Chinese medicine Dabu Ge. Methods: Silica gel and gel repeated column chromatography were used for separation. The components were identified by spectral analysis and physical and chemical properties. RESULTS: Eight components were identified and identified as meniscoside (1), dauricoside (2), dauriporphine (3), menisporphine (4), bianfugecine (5), 2,3- dihydromenisporphine (6), syringaresinol syringaresinol 4,4’-O-bis-glucoside (8). CONCLUSION: Compound 1 is a novel benzyl isoquinoline alkaloid glucoside. It was first reported that compounds 1-6 showed marked selective binding to D1 receptors in competitive binding to dopamine D1 and D2 receptors The IC50 of 1 and 2 were 9.2 and 2.0 μmol? L-1, respectively.