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实验观察了SOD和过氧化氢酶对大鼠盆腔粘连模型抗粘连形成的效应。以Brain报告的方法制造粘连模型。实验组分别给予SOD50000U/ml或SOD加过氧化氢酶各50000单位/ml;对照组给予同容积的生理盐水,均腹腔注射,共5天。9天后剖腹检查,结果为对照组粘连级别为3.00±1.23,SOD组为1.95±1.23;SOD加过氧化氢酶组为1.80±1.28。两实验组与对照组比差异均非常显著(P<0.01),两实验组间无显著差异。证明应用外源性SOD和过氧化氢酶对实验动物的粘连形成具有保护性作用,提示盆腔粘连形成与超氧自由基的存在并起一定作用有关。
The effects of SOD and catalase on the formation of anti-adhesion in rat pelvic adhesion model were observed. The adhesion model was made by the method reported by Brain. The experimental group were given SOD50000U / ml or SOD plus catalase 50000 units / ml; control group were given the same volume of saline, were injected intraperitoneally for 5 days. After 9 days of laparotomy, the results showed that in the control group, the adhesion level was 3.00 ± 1.23 and in the SOD group was 1.95 ± 1.23. The SOD plus catalase group was 1.80 ± 1.28. The difference between the two experimental groups and the control group was significant (P <0.01), no significant difference between the two experimental groups. Proved that the application of exogenous SOD and catalase on experimental animal adhesion formation has a protective effect, suggesting that the formation of pelvic adhesions and the existence of superoxide radicals play a role.