肠道外接种的伤寒菌苗(TAB)免疫后常伴有局部和全身不良反应,一种口服伤寒减毒活菌苗Ty21a的高免疫性和弱反应性已得到证明,作者比较了对两种菌苗的临床和免疫应答。 60名年龄为16～22岁的健康男性志愿者被分为两组,第1组在第0和28天皮下接种TAB,另1组在第0、2和4天口服Ty21a,随后分别在第0、15、30和240天采集血标本,在第0、30和240天收集粪便标本。 Post-immunization of typhoid vaccine (TAB) is often associated with local and systemic adverse reactions after immunization. The high immunogenicity and poor reactivity of an oral typhoid attenuated vaccine Ty21a have been demonstrated. Seedling’s clinical and immune response. Sixty healthy male volunteers, aged 16-22 years, were divided into two groups: group 1 received TAC subcutaneously on days 0 and 28, and group 1 received Ty21a orally on days 0, 2, and 4 followed by Blood samples were taken at 0, 15, 30 and 240 days, and stool samples were collected on days 0, 30 and 240.