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目的通过美常安干预肠易激综合征(IBS)伴小肠细菌过度生长(SIBO)患者,探讨IBS与SIBO之间的关系。方法选取40例IBS患者为IBS组,40例健康志愿者为对照组,两组患者治疗前均进行乳果糖氢呼气试验(LHBT)明确SIBO情况。IBS组中SIBO阳性者予美常安干预,观察其治疗前后的症状变化,疗程结束后复查LHBT。结果 IBS组患者SIBO发病率为55.0%,对照组为10.0%,两组患者SIBO发病率比较差异有统计学意义(P<0.05);IBS组中SIBO阳性患者治疗后显效1例,有效12例,无效6例,脱落3例,有效率为68.0%,SIBO转阴率为57.9%。IBS组中SIBO阳性患者治疗前后腹胀程度、排便频率异常时间、排便时腹痛率及总积分比较差异有统计学意义(P<0.05)。结论 IBS患者SIBO发病率远高于健康者,美常安能改善IBS伴SIBO患者部分症状及SIBO发病率,IBS的发生与SIBO之间存在一定关系,但对于IBS患者单纯补充益生菌制剂疗效并不理想,仍需结合其他手段进行干预。
Objective To explore the relationship between IBS and SIBO in patients with irritable bowel syndrome (IBS) accompanied by intestinal bacterial overgrowth (SIBO) through Mie Chang An. Methods Forty IBS patients were selected as IBS group and 40 healthy volunteers as control group. Both groups were given LHBT test before treatment. IBS group SIBO-positive to the United States and Changan intervention to observe the changes in symptoms before and after treatment, review the LHBT after the end of the course of treatment. Results The incidence of SIBO was 55.0% in IBS group and 10.0% in control group. There was significant difference in the incidence of SIBO between the two groups (P <0.05). In IBS group, the SIBO positive group was markedly effective in 1 case and effective in 12 cases , Ineffective in 6 cases, shedding in 3 cases, the effective rate was 68.0%, SIBO negative rate was 57.9%. IBS group SIBO-positive patients before and after treatment of abdominal distension, abnormal frequency of defecation, defecation abdominal pain rate and total score difference was statistically significant (P <0.05). Conclusions The incidence of SIBO in patients with IBS is much higher than that in healthy people. Meixuanan can improve some symptoms and the incidence of SIBO in IBS patients with SIBO. The incidence of IBS is related to SIBO. However, the effect of simply adding probiotics in patients with IBS is not Ideal, still need to be combined with other means to intervene.