论文部分内容阅读
用免疫组织化学方法研究了神经生长因子（ＮＧＦ）及其受体（ｔｒｋＡ）在正常金黄地鼠和过量维生素Ａ 酸致畸金黄地鼠胚胎神经管及其周围间充质的分布状况。结果显示：ＮＧＦ广泛分布于正常神经上皮及其内、外界膜和周围间充质中；实验组在服药后４６ｈ，上述各部位ＮＧＦ和ｔｒｋＡ 含量均明显减少。表明ＮＧＦ和ｔｒｋＡ 与神经管正常发生密切相关，其含量减少可能是过量维生素Ａ酸致神经管畸形的机制之一
The distribution of Nerve Growth Factor (NGF) and its receptor (trkA) in the neural tube and its surrounding mesenchyme of normal hamster and excess vitamin A acid-induced hamster embryos was studied by immunohistochemistry. The results showed that: NGF is widely distributed in the normal neural epithelium and its internal and external membrane and surrounding mesenchyme; 46 h after taking the experimental group, the above parts of the NGF and trkA levels were significantly reduced. The results suggest that NGF and trkA are closely related to normal neural tube formation, and their reduction may be one of the mechanisms by which excessive vitamin A acid causes neural tube defects