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目的 了解广州地区淋病奈瑟菌的耐药趋势，为防治淋病提供用药指导。方法 对分离到的１２４株淋病奈瑟菌选用青霉素、环丙沙星、四环素、壮观霉素和头孢曲松进行Ｋ－ Ｂ 法药敏试验，选用青霉素、环丙沙星、壮观霉素和头孢曲松进行Ｅ－ｔｅｓｔ 法药敏试验，同时用头孢硝噻吩进行β－ 内酰胺酶测定。结果 淋病奈瑟菌β－ 内酰胺酶阳性株（ＰＰＮＧ） 有１１－３ ％ 。Ｋ－ Ｂ法耐药率：青霉素６８－５％ 、环丙沙星８５－５％ 、四环素４７－６ ％ 、壮观霉素１－６％ 、头孢曲松６－５％ 。Ｅ－ｔｅｓｔ 法耐药率：青霉素３３－９％ 、环丙沙星８９－５％ 、壮观霉素１－６ ％ 、头孢曲松０－８％ 。结论 目前广州地区ＰＰＮＧ为１１－３ ％ ，四环素耐药率未见明显上升，环丙沙星耐药率明显高于１９９６ 年南京、重庆、合肥、福州等地的耐药率，表明氟喹诺酮类也已不能作为治疗淋病的首选药物。耐青霉素、四环素和环丙沙星的多重耐药菌株已达４１－９ ％ ，明显高于１９９６ 年国内１０－２６ ％ 水平。头孢曲松、壮观霉素仍是治疗淋病有效药物，但也应加强对其耐药性的监测，及时掌握耐药的趋势。比较Ｋ－ Ｂ法与Ｅ－ｔｅｓｔ 法检测方法比较，二种方法对４ 种抗生素的敏感率无明显差异，但在青?
Objective To understand the trend of drug-resistant Neisseria gonorrhoeae in Guangzhou and provide guidance for the prevention and treatment of gonorrhea. Methods A total of 124 isolates of Neisseria gonorrhoeae were screened for susceptibility to penicillin, ciprofloxacin, tetracycline, spectinomycin and ceftriaxone by K-B method. Penicillin, ciprofloxacin, spectinomycin and cefuroxime Qu Song for E-test method susceptibility testing, while using cefotaxime for β-lactamase determination. Results Neisseria gonorrhoeae beta-lactamase positive strain (PPNG) 11-3%. K-B resistance rate: penicillin 68-5%, 85-5% ciprofloxacin, tetracycline 47-6%, spectinomycin 1-6%, 6-5% ceftriaxone. E-test resistance rate: penicillin 33-9%, ciprofloxacin 89-5%, spectinomycin 1-6%, ceftriaxone 0-8%. Conclusions At present, the PPNG in Guangzhou is 11-3%, and the resistance rate of tetracycline is not obviously increased. The resistance rate of ciprofloxacin is obviously higher than that of Nanjing, Chongqing, Hefei and Fuzhou in 1996, indicating that fluoroquinolones Can not be used as the drug of choice for the treatment of gonorrhea. The multi-resistant strains resistant to penicillin, tetracycline and ciprofloxacin reached 41-9%, significantly higher than the domestic level of 10-26% in 1996. Ceftriaxone, spectinomycin is still an effective drug for the treatment of gonorrhea, but should also strengthen its monitoring of drug resistance, timely grasp of the trend of resistance. Comparing K-B method and E-test method, there is no significant difference between the two methods in the sensitivity of the four antibiotics,