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目的评价环孢素A(CsA)+甲氨喋呤(MTX)+霉酚酸酯(MMF)+抗胸腺细胞球蛋白(ATG)四联方案预防人类白细胞抗原(HLA)不全相合移植中的移植物抗宿主病(GVHD)的疗效。方法10例白血病和2例骨髓增生异常综合征患者分别接受HLA不全相合造血干细胞移植(HSCT)。预处理方案应用Flu+Bu+CTX;HLA1-3个位点不和。结果11例患者获得造血重建,急性GVHD(aGVHD)发生率7/11,慢性GVHD(cGVHD)发生率6/10,最长随访时间26个月,死亡率4/12。结论CsA+MTX+MMF+ATG可有效预防HLA不全相合移植中的GVHD,不影响造血重建,不增加移植相关死亡率和感染率。
Objective To evaluate the efficacy and safety of CsA + MTX plus mycophenolate mofetil (MMF) combined with anti-thymocyte globulin (ATG) regimen in the prevention of human leukocyte antigen (HLA) incompatibility Anti-host disease (GVHD) curative effect. Methods Ten patients with leukemia and two patients with myelodysplastic syndrome received HLA incompatible hematopoietic stem cell transplantation (HSCT). Pretreatment program using Flu + Bu + CTX; HLA1-3 sites and not. Results Eleven patients underwent hematopoietic reconstitution. The incidence of acute GVHD (aGVHD) was 7/11 and that of chronic GVHD (cGVHD) was 6/10. The longest follow-up time was 26 months and the mortality rate was 4/12. Conclusions CsA + MTX + MMF + ATG can effectively prevent GVHD in HLA-incompatible transplantation, does not affect hematopoietic reconstitution, does not increase graft-related mortality and infection rate.