Koch首次分离出结核菌已一百周年,尽管在结核病的免疫方面仍存有不少问题,但近10年来免疫学的进展,使人们能进一步了解到结核病各种类型的免疫反应。本文概述了有关结核病发病机理、诊断以及结核病免疫方面的知识。结核菌为了理解感染结核菌后的生物、病理和免疫方面的变化,首要了解结核菌的性质、成分及其作用方式。 Koch first isolated mycobacterium hundredth anniversary, despite the immunization of tuberculosis there are still many problems, but the progress of immunology in recent 10 years, so that people can learn more about the various types of tuberculosis immune response. This article provides an overview of the pathogenesis, diagnosis, and immunization of tuberculosis. Mycobacterium tuberculosis in order to understand the biological, pathological and immunological changes, the main understanding of the nature of TB, composition and mode of action.