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目的对比研究人工肝治疗中血浆置换、血液灌流的临床疗效。方法选择重型肝炎102例患者,在常规治疗的基础上随机分成两组,60例进行血浆置换治疗;42例进行血液灌流治疗,观察患者治疗前后TIB、ALB、PTA、NH3、Na、K、Crea、Urea的变化及临床症状改善。结果两组表现在TIB、ALB、PTA、NH3治疗前后有显著性差异(P<0.01);而Na+、K+、Crea、Urea治疗前后无显著性差异(P>0.05);两组治疗好转率比较:无显著性差异(P>0.05)。结论人工肝治疗中血浆置换、血液灌流的临床疗效无明显差异,主要并发症发生率有明显差异,因为血浆置换需大量血浆,治疗过程中患者总住院费用远远超过血液灌流。
Objective To compare the clinical effects of plasma exchange and hemoperfusion in the treatment of artificial liver. Methods Totally 102 patients with severe hepatitis were randomly divided into two groups on the basis of routine treatment, 60 patients were treated by plasma exchange, 42 patients were treated by hemoperfusion, TIB, ALB, PTA, NH3, Na, K, Crea , Urea changes and clinical symptoms improved. Results There was significant difference between before and after treatment of TIB, ALB, PTA and NH3 in both groups (P <0.01), while no significant difference was found between Na +, K +, Crea and Urea before and after treatment (P> 0.05) : No significant difference (P> 0.05). Conclusion The clinical efficacy of plasma exchange and hemoperfusion has no significant difference between the two groups. The incidence of major complications is obviously different because of the large amount of plasma required for plasma exchange. The total cost of hospitalization is much higher than that of blood perfusion during the treatment.