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肺耐药蛋白（ＬＲＰ）是一种可引起肿瘤多药耐药（ＭＤＲ）现象的蛋白，广泛存在于各种正常组织中，并在许多非Ｐｇｐ机制的ＭＤＲ肿瘤细胞中过度表达，阻滞作用于细胞核ＤＮＡ的化疗药物通过核孔进入细胞核或将胞核内药物泵出核外，并通过囊泡转运和胞吐作用排出细胞外而引起肿瘤ＭＤＲ。能介导对铂类、烷化剂等Ｐｇｐ和多药耐药相关蛋白（ＭＲＰ）所不能介导药物的耐药。ＬＲＰ与卵巢癌等多种肿瘤的临床化疗敏感性有关，在某些肿瘤可作为预测治疗预后的指标
Lung resistance protein (LRP) is a protein that causes multidrug resistance (MDR) in tumors. It is widely expressed in various normal tissues and overexpressed and blocked in many non-Pgp-mediated MDR tumor cells Chemotherapy drugs in the nuclear DNA enter the nucleus through the nuclear pore or pump the nucleus drug out of the nucleus and cause tumor MDR through vesicle transport and exocytosis. Can mediate platinum, alkylating agents such as Pgp and multidrug resistance-related protein (MRP) can not mediate drug resistance. LRP is associated with the clinical chemosensitivity of a variety of tumors, including ovarian cancer, and can be used as a predictor of prognosis in some tumors