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应用放免技术测定了马桑内酯致痫和对照组大鼠大脑皮层和海马脑组织皮质醇含量及血清皮质醇水平结果显示，血清对照组为２．７７±２．０７ｎｇ／ｍｌ，致痫组为０．９８±０．７５ｎｇ／ｍｌ，两组比较无显著差异（Ｐ＞０．０５）；海马正常对照组为２５．７７±１２．９８ｎｇ／ｇ湿重，致痫组为０．９８±０．４２ｎｇ／ｇ湿重组织，海马致痫组显著降低（Ｐ＜０．０１）；大脑皮层对照组为８．８３±１．９６ｎｇ／ｇ湿重，致痫组为０．３３±０．１１ｎｇ／ｇ湿重组织，大脑皮层致痫组降低极为显著（（Ｐ＜０．００１）。表明致痫后大鼠大脑皮层、海马脑组织皮质醇含量均明显降低，提示皮质醇在癫痫的发病中起重要作用。
The application of radioimmunoassay to determine the cortisol levels and serum cortisol levels in the cerebral cortex and hippocampus of rats with epilepsy induced by docetaxel and the control group showed that the serum control group was 2.77 ± 2.07ng / (0.98 ± 0.75ng / ml), there was no significant difference between the two groups (P> 0.05); the normal control group was 25.77 ± 12.98ng / g wet weight, the epileptic group was 0.98 ± 0.42 ng / g wet tissue and hippocampus epilepsy group (P <0.01). The cerebral cortex control group was 8.83 ± 1.96 ng / g wet weight and the epileptic group was 0.33 ± 0. 11ng / g wet weight tissue, cerebral cortex epileptogenic group decreased significantly (P <0.001) .It shows that the cortisol content of cerebral cortex and hippocampus in rats after epilepsy were significantly reduced, suggesting that the incidence of cortisol in epilepsy Play an important role.