论文部分内容阅读
目的探讨哮喘患儿血清中肺表面活性蛋白A、D(SP-A,SP-D)、白介素8(IL-8)、免疫球蛋白E(IgE)含量的变化及其分析研究。方法测定30例儿童哮喘急性发作期和缓解期的SP-A、SP-D、IL-8、IgE及同期健康儿童30例。结果急性发作期的SP-A、SP-D水平均显著低于对照组(P<0.01),IL-8、IgE水平均显著高于对照组(P<0.01);缓解期的SP-A、SP-D水平明显高于发作期(P<0.05),IL-8水平明显低于发作期(P<0.05),IgE水平与发作期相比差异无显著性(P>0.05)。结论儿童哮喘的发作虽然是多种病因引起,IL-8、IgE等在其中的病理生理、免疫病理改变有重要作用。证明SP-A、SP-D含量及功能改变与哮喘的发病、发展关系密切。
Objective To investigate the changes of serum surfactant protein A, D (SP-A, SP-D), interleukin 8 (IL-8) and IgE in children with asthma. Methods Thirty children with asthma attack and remission of acute phase and remission of SP-A, SP-D, IL-8, IgE and 30 healthy children at the same period. Results The levels of SP-A and SP-D in acute exacerbation were significantly lower than those in control group (P <0.01), and the levels of IL-8 and IgE in acute exacerbation were significantly higher than those in control group (P <0.01) The level of SP-D was significantly higher than the onset (P <0.05), and the level of IL-8 was significantly lower than the onset (P <0.05). The level of IgE was not significantly different from the onset (P> 0.05). Conclusions Although the onset of childhood asthma is caused by many causes, the pathophysiological and immunopathological changes such as IL-8 and IgE play an important role. Proved SP-A, SP-D content and function changes and asthma incidence and development are closely related.