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目的:整理我院高孕中期孕妇的临床检查资料,探讨孕中期唐氏综合症筛查产前诊断的临床意义。方法:选取我院2014年1月至2015年1月收治的568例孕中期孕妇,对所选孕妇进行孕中期三联血清生化指标检测,并通过计算机预测,将高风险孕妇进行选择性检查,检查主要内容为超声检查、羊水检查以及脐带血染色体核型检查等。对孕妇的检查结果进行分析和比较。结果:所选孕妇中,年龄≥35岁的孕妇为58例,占所选孕妇总数的10.21%,三联血清生化指标检验后阳性孕妇为129例,占所选孕妇总数的22.71%,阳性孕妇中,通过脐带血穿刺或羊水穿刺检查出胎儿染色体异常的例数为75例,占所选孕妇总数的13.20%。结论:孕中期唐氏筛查能够准确的反映出患儿的发育状况,并根据孕妇的羊水穿刺以及脐带血穿刺检查结果,能够准确的诊断出胎儿是否出现严重的缺陷,对优生优育,提高新生儿素质具有非常高的价值,值得临床推广应用。
OBJECTIVE: To sort out the data of clinical examination of pregnant women in the second trimester of pregnancy in our hospital and explore the clinical significance of prenatal diagnosis of Down’s syndrome in the second trimester of pregnancy. Methods: A total of 568 pregnant women of the second trimester who were admitted to our hospital from January 2014 to January 2015 were enrolled in the study. The pregnant women were tested for the third trimester serum biochemical markers and computerized prediction of high risk pregnant women, The main contents of ultrasound examination, amniotic fluid examination and cord blood karyotype examination. The examination results of pregnant women were analyzed and compared. Results: Among the selected pregnant women, 58 pregnant women ≥35 years of age, accounting for 10.21% of the total number of selected pregnant women, 129 positive pregnant women after triple serum biochemical tests, accounting for 22.71% of the total number of selected pregnant women, positive pregnant women , 75 cases of fetal chromosomal abnormalities were detected by cord blood puncture or amniocentesis, accounting for 13.20% of the total number of selected pregnant women. Conclusion: Down’s screening in the second trimester can accurately reflect the development of children. According to the results of amniocentesis and cord blood puncture, it can accurately diagnose whether the fetus has serious defects, Children’s quality has a very high value, it is worth clinical application.