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在血液透析单位的患者中,采用双盲法,分别注射抗HBs免疫球蛋白(HBIG)或无抗HBs的正常人的免疫球蛋白(NHIG),并进行对比,以研究HBIG预防HBsAg血症的效果。被试者无肝炎的病史,在试验前6个月期间,进行逐月检查,均未测出HBsAg、抗HBs、抗HBc。无选择地对29名被试者分别肌注NHIG或HBIG 5毫升。两组例数基本相等。6个月后再同样地注射第二次。在试验后的16个月内,逐月检查血清中的HBsAg、抗HBc、抗HBs,并测定转氨酶。应用放射免疫法检测HBsAg,并定出亚型;应用间接血凝检测抗HBs;应用对流电泳、补体结合反应检测抗
In hemodialysis units, immunoglobulins (NHIGs) were injected in double-blind, anti-HBs immunoglobulin (HBIG) or normal human anti-HBs non-HBs respectively and compared to study the effect of HBIG on prevention of HBsAg effect. Subjects without a history of hepatitis, during the first 6 months before the test, conducted monthly inspection, were not detected HBsAg, anti-HBs, anti-HBc. None of the 29 subjects were intramuscularly injected with 5 ml NHIG or HBIG. The two groups of cases are basically the same. 6 months after the same injection the second time. Serum HBsAg, anti-HBc, anti-HBs, and aminotransferase were tested monthly for 16 months after the test. Application of radioimmunoassay detection of HBsAg, and set subtypes; application of indirect blood coagulation detection of anti-HBs; application of convection electrophoresis, complement fixation reaction detection