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目的:探讨特发性胎儿生长受限(IFGR)胎盘组织中Toll样受体2(TLR2)、Toll样受体4(TLR4)的表达及意义,讨论IFGR的可能病因及发病机制。方法:选取我院2009年6月~2010年4月剖宫产分娩的IFGR孕妇30例为实验组,剖宫产分娩的正常足月孕妇30例为对照组。用免疫组化法检测胎盘组织TLR2、TLR4的表达水平。结果:(1)实验组及对照组的胎盘组织中均有TLR2、TLR4蛋白不同程度的阳性表达;(2)实验组TLR2、TLR4在胎盘合体滋养细胞上的表达高于对照组,差异有统计学意义(P<0.05)。结论:胎盘组织中TLR2、TLR4表达增加促使了IFGR的发生,可能是IFGR发病机制中的关键环节之一,为临床上应用免疫干预手段预防或治疗IFGR提供了依据。
Objective: To investigate the expression and significance of Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) in idiopathic fetal growth-limited (IFGR) placentas and to discuss the possible etiology and pathogenesis of IFGR. Methods: 30 cases of IFGR pregnant women who were delivered by cesarean section in our hospital from June 2009 to April 2010 were selected as the experimental group. 30 normal pregnant women under cesarean section were given as control group. The expression of TLR2 and TLR4 in placenta was detected by immunohistochemistry. Results: (1) The levels of TLR2 and TLR4 protein in placenta of experimental group and control group were all significantly different; (2) The expression of TLR2 and TLR4 in placental syncytiotrophoblast was higher in experimental group than in control group Significance (P <0.05). CONCLUSION: The increased expression of TLR2 and TLR4 in placenta contributes to the occurrence of IFGR, which may be one of the key links in the pathogenesis of IFGR. It provides a basis for the clinical application of immune intervention to prevent or treat IFGR.