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通常认为两性霉素B是抗真菌剂中的标准疗法用药,特别是对包括隐球菌在内的全身性真菌病的治疗。两性霉素B常用于治疗AIDS患者的隐球菌病。然而,用药的总剂量差异很大,其范围为0.9-5.08g,治疗的最佳剂量尚未确定。作者观察肺隐球菌病患者8例,以便提供更多的两性霉素B和临床疗效之间关系的资料,其中行支气管肺泡冲洗6例;痰培养1例;胸膜活检1例,结果均证实有新型隐球菌感染。在接受两性霉素B2g治疗后,对疑有
Amphotericin B is generally considered as a standard therapy in antifungal agents, especially for the treatment of systemic fungal diseases including cryptococcosis. Amphotericin B is commonly used to treat cryptococcosis in AIDS patients. However, the total dose varies greatly, ranging from 0.9 to 5.08 g and the optimal dosage for treatment has not been established. The authors observed in 8 patients with pulmonary cryptococcosis in order to provide more information on the relationship between amphotericin B and clinical efficacy, including bronchoalveolar lavage in 6 cases; sputum culture in 1 case; pleural biopsy in 1 case, the results were confirmed with Cryptococcus neoformans infection. After receiving amphotericin B2g treatment, the suspect