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我院于1995～1997年对93例新生儿缺氧缺血性脑病(HIE)患儿在常规治疗基础上加用神经生长因子治疗,疗效满意。现报告如下:1 临床资料 观察对象186,例均符合1989年8月济南会议制定的新生儿缺氧缺血性脑病诊断标准,随机分为治疗组及对照组各93例。治疗组:男58例,女35例,其中早产13例。足月产76例,过期产4例;分度:重度缺氧缺血性脑病5例,中度61例,轻度27例。对照组:男54例,女39例,其中早产17例,足月产71例,过期产5例;分度:重度缺氧缺血性脑病7例,中度61例,轻度25例。全部186例均做头颅CT检查,其中不同程度颅内出血,治疗组9例,对照组13例,余164例均表现为脑实质密度改变。
93 cases of neonates with hypoxic-ischemic encephalopathy (HIE) were treated with NGF in our hospital from 1995 to 1997, and the results were satisfactory. The report is as follows: 1 clinical data observed 186 cases were in line with the diagnostic criteria of neonatal hypoxic-ischemic encephalopathy developed in August 1989 meeting in Jinan, were randomly divided into treatment group and control group of 93 cases. Treatment group: 58 males and 35 females, of which 13 cases of preterm birth. 76 cases of full-term birth, 4 cases of obsolete; Index: 5 cases of severe hypoxic-ischemic encephalopathy, moderate in 61 cases, mild in 27 cases. Control group: 54 males and 39 females, of which 17 cases of preterm birth, full-term birth in 71 cases, 5 cases of obsolete; Index: Severe hypoxic-ischemic encephalopathy in 7 cases, 61 cases of moderate, mild in 25 cases. All 186 patients underwent craniofacial CT examination. Among them, 9 patients in the treatment group and 13 patients in the control group had intracranial hemorrhage with varying degrees. The remaining 164 patients all showed changes in brain parenchyma density.