论文部分内容阅读
目的 观察肿瘤患者血清ＴＮＦ－ａ的变化及临床意义。方法 应用放射免疫测定法对２０例健康对照者和 ７０例肿瘤患者进行了血清 ＴＮＦ－ａ含量测定。结果 对照组血清 ＴＮＦ－ａ的含量较低，肿瘤患者明显升高（Ｐ＜０．０１）；肿瘤转移和／或复发时无进一步上升，而肿瘤合并胸腹水和恶液质时ＴＮＦ－ａ上升明显。结论 肿瘤患者血清的ＴＮＦ－ａ水平明显高于对照组，随着肿瘤的局部控制及消退，体内ＴＮＦ－ａ含量呈下降趋势。因此，ＴＮＦ－ａ含量的变化对肿瘤患者病情变化及预后的判定，具有一定的参考价值。
Objective To observe the changes and clinical significance of serum TNF-a in tumor patients. Methods Radioimmunoassay was used to measure serum TNF-a levels in 20 healthy controls and 70 cancer patients. Results The levels of serum TNF-a in the control group were lower, and the tumor patients were significantly elevated (P<0.01). No further increase in tumor metastasis and/or recurrence occurred. However, TNF-a increased in tumors with pleural effusion and hemorrhage. obvious. Conclusion The serum level of TNF-a in tumor patients was significantly higher than that in the control group. With the local control and regression of tumor, the level of TNF-a in the tumor showed a decreasing trend. Therefore, the change of TNF-a content has certain reference value for the determination of the patient’s condition and prognosis.