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目的:探讨急性脑梗死患者血清同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)与颈动脉粥样硬化的相关性及临床意义。方法:收集确诊为急性脑梗死患者90例,对患者进行颈动脉超声检查,根据颈动脉狭窄程度将患者分成颈动脉内膜正常组、轻度狭窄组、中-重度狭窄组。比较三组患者斑块检出率、Hcy、hs-CRP水平和IMT厚度,同时对Hcy、hs-CRP与IMT进行相关性分析。结果:中-重度狭窄组斑块检出率为86.4%,显著高于轻度狭窄组和颈动脉内膜正常组(P<0.05);颈动脉内膜正常组Hcy、hs-CRP水平以及IMT厚度均显著低于颈动脉轻度狭窄组、中-重度狭窄组(P<0.05);hs-CRP与IMT呈正相关(r=0.71,P<0.05);Hcy与IMT呈正相关(r=0.79,P<0.05)。结论:血清Hcy和hs-CRP水平与颈动脉粥样硬化程度密切相关,Hcy、hs-CRP联合检测对急性脑梗死的早期诊断和预后有着重要临床意义。
Objective: To investigate the correlation and clinical significance of serum homocysteine (Hcy), high sensitivity C-reactive protein (hs-CRP) and carotid atherosclerosis in patients with acute cerebral infarction. Methods: Totally 90 patients diagnosed as acute cerebral infarction were collected. Carotid ultrasonography was performed on the patients. According to the degree of carotid artery stenosis, the patients were divided into normal carotid intima, mild stenosis group and moderate-severe stenosis group. The plaque detection rate, Hcy, hs-CRP level and IMT thickness were compared between the three groups. Hcy, hs-CRP and IMT were also analyzed. Results: The detection rate of plaque in moderate-severe stenosis group was 86.4%, which was significantly higher than that in mild stenosis group and normal carotid artery intima (P <0.05). The levels of Hcy, hs-CRP and IMT CRP was positively correlated with IMT (r = 0.71, P <0.05); Hcy was positively correlated with IMT (r = 0.79, P < P <0.05). Conclusions: Serum Hcy and hs-CRP levels are closely related to the degree of carotid atherosclerosis. Combined detection of Hcy and hs-CRP has an important clinical significance in the early diagnosis and prognosis of acute cerebral infarction.