【摘 要】
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BACKGROUND AND OBJECTIVEPrevious studies have demonstrated an association between an increased risk of ischemic stroke and a genetic variant on chromosome 7p21.1. The underlying gene is thought to be
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BACKGROUND AND OBJECTIVEPrevious studies have demonstrated an association between an increased risk of ischemic stroke and a genetic variant on chromosome 7p21.1. The underlying gene is thought to be a histone deacetylase 9 (HDAC9). As sodium valproate (SVA) is an inhibitor of HDAC9, this study explored the association between exposure to SVA and the subsequent risk of recurrent stroke.
METHODSData for this study were pooled from three prospective studies of patients with previous stroke or transient ischemic attack (TIA). These included the South London Stroke Register, the Vitamins To Prevent Stroke Study, and the Oxford Vascular Study. Data included in the analysis were age, sex, diagnosis of epilepsy, medications, and included SVA exposure before recurrent stroke. The SVA exposure populations were compared with control populations. Survival time was calculated from the index event (stroke or TIA) to the date of recurrent stroke.
RESULTSA total of 11，949 patients were included in the analysis, all with a confirmed ischemic event at entry. Compared with other antiepileptic drugs, the recurrent stroke rate was lower among those taking SVA (P＝0.002).
CONCLUSIONThis study of patients with ischemic stroke or transient ischemic attack found that exposure to sodium valproate may be associated with a lower risk of recurrent events.
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