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目的:探讨细胞因子IL-2、IL-6与TGF-β1水平对精索静脉曲张的男性患者生育的影响。方法:检测60例精索静脉曲张的男性患者和20例正常男性精液常规,同时应用酶联免疫吸附实验(ELISA)对两组精浆中细胞因子IL-2、IL-6与TGF-β1水平进行了检测。结果:精索静脉曲张患者精液质量明显低于正常男性,精索静脉曲张患者精浆中细胞因子IL-2、IL-6和TGF-β1含量均高于正常男性组,差异均有统计学意义(P<0.05)。结论:精索静脉曲张患者精液质量与精浆中细胞因子IL-2、IL-6与TGF-β1水平变化有关,检测精浆中IL-2、IL-6、TGF-β1的含量可以反映男性精液质量。
Objective: To investigate the effects of cytokines IL-2, IL-6 and TGF-β1 on the fertility of male patients with varicocele. Methods: Sixty male patients with varicocele and 20 normal male semen routine tests. Serum IL-2, IL-6 and TGF-β1 levels were measured by enzyme-linked immunosorbent assay (ELISA) Tested. Results: The semen quality of patients with varicocele was significantly lower than that of normal males. The content of cytokines IL-2, IL-6 and TGF-β1 in patients with varicocele were significantly higher than those in normal males (P <0.05). CONCLUSIONS: The sperm quality of patients with varicocele correlates with the changes of cytokines IL-2, IL-6 and TGF-β1 in seminal plasma. The content of IL-2, IL-6 and TGF- Semen quality.