约50～70%的自然流产,组织学检查提示胚胎发育缺陷。约90%异常或枯萎卵为染色体畸型,提示妊娠时已有疾病。30～50%病例可找到胚胎经常已经浸软,提示发育紊乱常常直接与结构上先天畸形有关。目前还不清楚胚胎死亡的许多病例中观察到绒毛各种病理改变是由于死后变化,还是胚胎发育缺陷所致。有报告认为染色体畸形如多倍体与绒毛水肿的发生率较高是平行的。血管生成发生在妊娠后第2周的绒毛中胚层,血管和生血系统首先起源于胚外区。在妊娠后第四周开始胎儿胎盘循环。作者研究的目的是测定胚胎发育和绒毛膜的绒毛血管形成状态之间的关系。作者将61例妊娠头3个月自然流产,10例妊娠头3个月行合法流产病人仅有超声资料和系列含绒毛的显微镜切片共50例分为3组:第1组:头3个月行合法流产(10例)。第2 About 50 to 70% of spontaneous abortion, histological examination prompted embryonic development defects. About 90% of abnormal or withered eggs are chromosomal abnormalities, suggesting that there is a disease during pregnancy. 30 to 50% of cases can be found embryos often have been soaked, suggesting that developmental disorders are often directly related to the structural congenital malformations. It is unclear in many cases of embryo death that the various pathological changes in the villus are due to post-mortem changes or defects in embryonic development. There are reports that chromosomal abnormalities such as polyploidy and villus edema is relatively high incidence of parallel. Angiogenesis occurs in the villus mesoderm during the second week of gestation, with the vascular and hematopoietic system first originating in the extraembryonic region. Fetal placental circulation begins in the fourth week after pregnancy. The purpose of the authors’ study was to determine the relationship between embryonic development and chorionic villus formation. The authors divided 61 patients with spontaneous abortion in the first trimester of pregnancy and 10 patients with licit abortion in the first trimester of pregnancy with only ultrasound data and series of villi-containing microscopic sections into 3 groups: Group 1: first 3 months Legitimate abortion (10 cases). 2nd