论文部分内容阅读
目的:在社区人群中探讨前清蛋白与代谢综合征及胰岛素抵抗的相关性。方法:按照整群抽样的方法选取上海市嘉定区社区40岁以上居民共2 446名,采集受试者基本信息并测量相关人体学指标,测定血脂、血糖、前清蛋白等生化指标。根据2001年美国国家胆固醇教育计划成人治疗组第3次报告(NCEP-ATPⅢ)诊断标准定义代谢综合征。Pearson相关分析前清蛋白与代谢综合征各个组分以及胰岛素抵抗的相关性。Logistic回归分析前清蛋白与代谢综合征的患病风险之间的关系。结果:随着前清蛋白水平的增加,体质量指数、腰围、三酰甘油、总胆固醇、低密度脂蛋白胆固醇、收缩压、舒张压、空腹胰岛素浓度均升高(均P<0.01),而高密度脂蛋白胆固醇降低(P<0.000 1)。Pearson相关性分析结果提示,前清蛋白水平与胰岛素素抵抗指数显著正相关(P<0.000 1)。按照前清蛋白四分位切点将人群分为4组,第1分位组到第4分位组人群代谢综合征的患病率分别为26.04%、34.71%、36.62%和41.91%(组间趋势P<0.000 1)。以前清蛋白第1分位组为参照组,校正年龄、性别、吸烟和饮酒状况、运动情况以及肾小球滤过率后,第2至第4分位组的代谢综合征的患病风险分别增加39%[比值比(OR)=1.39,95%可信区间(CI):1.04-1.85]、52%(OR=1.52,95%CI:1.13-2.03)和114%(OR=2.14,95%CI:1.60-2.87)。结论:中老年人群中,前清蛋白水平与胰岛素抵抗相关。前清蛋白水平升高可能增加代谢综合征的患病风险。
OBJECTIVE: To investigate the relationship between prealbumin and metabolic syndrome and insulin resistance in community population. Methods: According to the method of cluster sampling, a total of 2 446 residents over the age of 40 in community of Jiading District of Shanghai were selected to collect the basic information of subjects and to measure the relevant anthropometric indexes. The biochemical indexes such as serum lipids, blood glucose and prealbumin were measured. Metabolic syndrome was defined according to the NCEP-ATP III diagnostic criteria of the 2001 National Cholesterol Education Program Adult Treatment Unit. Pearson correlation analysis of prealbumin with various components of metabolic syndrome and insulin resistance. Logistic regression analysis of the relationship between prealbumin and the prevalence of metabolic syndrome. Results: Body mass index, waist circumference, triglyceride, total cholesterol, low density lipoprotein cholesterol, systolic blood pressure, diastolic blood pressure and fasting insulin concentration increased with the increase of prealbumin levels (all P <0.01) High-density lipoprotein cholesterol decreased (P <0.000 1). Pearson correlation analysis suggested that prealbumin levels were positively correlated with insulin resistance index (P <0.000 1). The population was divided into four groups according to the pre-albumin quadruple point, and the prevalence rates of metabolic syndrome were 26.04%, 34.71%, 36.62% and 41.91% in group 1 and group 4, respectively Inter-trend P <0.000 1). The first group of albumin as a reference group, the correct age, gender, smoking and drinking status, exercise and glomerular filtration rate, the second to the fourth inter-group metabolic syndrome risk (OR = 1.39, 95% CI: 1.04-1.85], 52% (OR = 1.52, 95% CI: 1.13-2.03) and 114% (OR = 2.14, 95% % CI: 1.60-2.87). CONCLUSION: Pre-albumin levels are associated with insulin resistance in the elderly population. Prealbumin levels may increase the risk of metabolic syndrome.