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目的总结喉鳞癌不同治疗方式对患者生存率的影响,并对其预后及影响因素进行分析。方法回顾性分析1998年2月—2008年2月经病理证实的初治的喉鳞癌患者62例,采用Kaplan-Meier法和Log-rank检验进行生存分析,多因素分析采用Cox回归模型。结果 62例喉鳞癌总的5年生存率为72.6%,手术+放疗组、单纯手术组及单纯放疗组5年生存率分别为82.1%、58.2%和39.8%,三组间生存率差异有统计学意义(P<0.05),有淋巴结转移患者5年生存率为46.7%,无淋巴结转移的为71.2%,差异有统计学意义(χ2=8.96,P<0.01)。Cox多因素分析显示T分期、淋巴结转移和治疗方式是主要的预后指标。结论综合治疗是喉鳞状细胞癌的主要治疗方式,积极采取综合治疗方式可有效延长患者的生存期提高生存率。
Objective To summarize the effects of different treatment modalities on the survival rate of patients with laryngeal squamous cell carcinoma and to analyze their prognosis and influencing factors. Methods Sixty-two patients with pathologically confirmed laryngeal squamous cell carcinoma were retrospectively analyzed. Survival analysis was performed by Kaplan-Meier method and Log-rank test. Cox regression was used for multivariate analysis. Results The overall 5-year survival rate of 62 cases of laryngeal squamous cell carcinoma was 72.6%. The 5-year survival rates of operation + radiotherapy group, operation alone group and radiotherapy alone group were 82.1%, 58.2% and 39.8%, respectively Statistical significance (P <0.05). The 5-year survival rate was 46.7% in patients with lymph node metastasis and 71.2% in patients without lymph node metastasis (χ2 = 8.96, P <0.01). Cox multivariate analysis showed that T stage, lymph node metastasis and treatment were the main prognostic indicators. Conclusion Comprehensive treatment is the main treatment for laryngeal squamous cell carcinoma, and aggressive treatment can effectively prolong the survival of patients and improve the survival rate.