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以银杏提取物为模型药物,初步探讨以药理指标评价缓释制剂的可行性。选择抗氧化和抗血小板聚集2个药理指标,考察影响因素,建立药理指标测定方法,并用该方法测定银杏制剂体外溶出液的生物效应,绘制时间-药理指标效应曲线,与时间-累积释放度曲线比较。试验显示体外释放度评价中药理指标与成分指标有较好相关性,初步说明药理指标可以用来评价中药缓释制剂。
Ginkgo biloba extract as a model drug, to explore the feasibility of pharmacological indicators of sustained-release preparations. The two pharmacological indexes such as anti-oxidation and anti-platelet aggregation were selected, the influencing factors were investigated, and the method for determining the pharmacological index was established. The biological effect of the in vitro dissolution solution of Ginkgo biloba preparation was determined, the time-pharmacological index effect curve was plotted, and the time-cumulated release curve Compare Experiments show that the evaluation of in vitro release of pharmacological indicators and composition of indicators have a good correlation, preliminary description of pharmacological indicators can be used to evaluate traditional Chinese medicine sustained-release preparations.