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探讨血管内皮生长因子（ＶＥＧＦ）在星形细胞瘤中表达与星形细胞瘤组织学分级和患者年龄的关系。方法应用免疫组化方法检测５２例星形细胞瘤石蜡包埋病理切片。结果ＶＥＧＦ在不同病理级别星形细胞瘤中表达程度不同，随组织级别增加，表达增强。ＶＥＧＦ高表达组患者平均年龄高于低表达组。结论ＶＥＧＦ与星形细胞瘤生长及恶性进展关系密切，ＶＥＧＦ高表达与高龄有关，预示预后不良。
To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) in astrocytoma and the histological grade and age of astrocytomas. Methods 52 paraffin-embedded pathological sections of astrocytomas were detected by immunohistochemistry. Results The expression levels of VEGF in astrocytoma with different pathological grades were different. With the increase of tissue grade, the expression was increased. The average age of patients with high VEGF expression was higher than those with low expression. Conclusion VEGF is closely related to the growth and progression of astrocytoma. The high expression of VEGF is associated with advanced age and predicts a poor prognosis.