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目的 定量测定孔源性视网膜脱离患者视网膜下液中转化生长因子β_1的含量,探讨转化生长因子β_1与增殖性玻璃体视网膜病变程度的相对应关系。方法 采集30例行孔源性视网膜脱离复位术患者的视网膜下液,用TGF-β_1试剂盒进行检测。结果 30例视网膜脱离患者视网膜下液中均含有TGF-β_1,SRF中TGF-β_1含量随着病程的延长而增加,随着PVR严重程度的增加而增加。结论 在PVR形成的过程中,随着PVR程度的增加,视网膜下液中TGF-β_1的含量随之增加,这可能为细胞迁移、增殖、膜收缩形成的原因。将来也许可以用拮抗TGF-β_1的方法去预防和治疗PVR的形成。
Objective To quantitatively determine the content of transforming growth factor-β1 in subretinal fluid of patients with rhegmatogenous retinal detachment and to investigate the relationship between TGF-β1 and the degree of proliferative vitreoretinopathy. Methods Thirty patients with subretinal fluid from patients with rhegmatogenous retinal detachment were collected and tested by TGF-β_1 kit. Results All 30 retinal detachment patients contained TGF-β 1 in the subretinal fluid. The content of TGF-β 1 in SRF increased with the duration of the disease and increased with the severity of PVR. Conclusions During PVR formation, the content of TGF-β 1 in subretinal fluid increases with the increase of PVR, which may be the reason of cell migration, proliferation and membrane contraction. In the future, it may be possible to prevent and treat PVR formation by antagonizing TGF-β_1.