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目的 :探讨中国汉人MG易感性与HLA DQB1基因多态性的相关性。方法 :运用PCR RFLP法进行HLA DQB1基因分型。结果 :MG病例组 (包括亚组 )与对照组比较都有DQB1 0 30 3频率的明显增高 ,DQB1 0 6 0 1和DQB1 0 6 0 2频率的明显降低 ,差异都有显著性。结论 :DQB1 0 30 3参与中国汉人MG的易感性 ,而DQB1 0 6 0 1和DQB1 0 6 0 2是保护基因
Objective: To investigate the correlation between MG susceptibility and HLA DQB1 gene polymorphism in Han Chinese. Methods: HLA DQB1 genotyping was performed by PCR RFLP. Results: The frequency of DQB1 0303 was significantly increased in MG patients (including subgroups) compared with the control group. The frequencies of DQB1 0601 and DQB1 0602 were significantly lower than those in control group. CONCLUSION: DQB1 0 30 3 participates in the susceptibility of Chinese Han Chinese while DQB1 0 601 and DQB1 0 602 are protective genes