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目的:研究益气活血法治疗顺铂所致肢体神经毒性病变临床效果。方法:随机选取东莞康华医院2014年7月至2016年7月收治的经化疗治疗后出现肢体神经毒性病变的患者78例,按照随机原则将所有患者均分为观察组与对照组。所有患者均给予神经节苷酯注射治疗,观察组39例在此基础上给予益气活血方对患者患肢进行浸泡以及口服治疗,对照组39例患者给予温水浸泡,2周后比较两组患者临床治疗效果以及治疗前后神经病变分级的变化情况。结果:观察组治疗有效率97.4%明显高于对照组84.6%,组间比较,差异具有统计学意义(P<0.05)。治疗后观察组神经毒性在1级以及1级以下的患者有38例者,对照组有34例,差异具有统计学意义(P<0.05)。结论:对于顺铂化疗所致肢体神经毒性病变患者给予益气活血方浸泡治疗,可以有效改善患者四肢麻木、疼痛、感觉障碍等主要临床症状。
Objective: To study the clinical effect of Yiqi Huoxue Therapy on limb neurotoxicity caused by cisplatin. Methods: Totally 78 patients with limb neurotoxicity after chemoradiotherapy were treated randomly from July 2014 to July 2016 in Dongguan Kanghua Hospital. All patients were randomly divided into observation group and control group according to the randomized principle. All patients were treated with ganglioside injection. In the observation group, 39 cases were treated with Yiqi Huoxue decoction for limb soaking and oral treatment, 39 cases in the control group were treated with warm water, and after 2 weeks, the patients in both groups were compared Clinical treatment and neuropathy classification before and after treatment changes. Results: The effective rate of treatment in observation group was significantly higher than that in control group (97.4% vs 84.6%). There was significant difference between groups (P <0.05). After treatment, there were 38 cases of neurotoxicity in grade 1 and grade 1 in the observation group and 34 cases in the control group, the difference was statistically significant (P <0.05). Conclusion: The treatment of Yiqihuoxue Decoction in patients with limb neurotoxicity caused by cisplatin chemotherapy can effectively improve the main clinical symptoms such as numbness, pain and sensory disturbance in patients with limbs.