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癌症所致非转移性神经疾病又称“副肿瘤综合征”或癌对神经系统的“远隔作用”。有关报道甚多,而癌性非转移性神经肌综合征(carcinoma of non-metastatic neuromuscular syndrome,CNNS)则最为常见和引人注目。尤其值得注意的是癌症非转移作用影响神经系统,其中50％病例的症状是在癌症确诊前出现。早在1888年,Oppenheim首先报道了癌症与神经肌肉异常有一定关系。1948年Denny-Brown报告2例癌症的远隔作用而致不能行走,并有严重感觉缺失。1958年以后Brain等把伴有癌症的神经综合征称为“神经肌病”。近年来神经生理和神经病理学研究将凡因癌症的“远隔作用”所引起的周围神经
Non-metastatic neuropathy caused by cancer, also known as “paraneoplastic syndrome” or cancer of the “remote effect of the nervous system.” There are a lot of reports about it, while the most common and conspicuous is the carcinoma of non-metastatic neuromuscular syndrome (CNNS). Of particular note is that the non-metastatic effect of the cancer affects the nervous system, with symptoms of 50% of cases occurring prior to the diagnosis of cancer. As early as 1888, Oppenheim first reported a relationship between cancer and neuromuscular abnormalities. In 1948 Denny-Brown reported two cases of cancer can not walk away from the role of long-term, and there is a serious loss of sensation. After 1958, Brain et al. Referred to the neurological syndrome associated with cancer as “neuromyopathy.” In recent years, neurophysiological and neuropathological studies will be due to cancer, “remote effect” caused by peripheral nerve