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目的观察Ｘ线引导下肺癌介入化疗的疗效。方法Ｘ线引导下肺穿直接介入化疗治疗２３例晚期肺癌。非小细胞肺癌２１例，小细胞肺癌２例。Ⅲ期１７例，Ⅳ期６例。药物为吡柔比星（ＴＨＰ）４０～６０ｍｇ／ｍ２、长春新碱２ｍｇ和卡铂４００ｍｇ／ｍ２，稀释至１０～２０ｍｌ，每３周一次，三次为１疗程，共９５例次。结果完全缓解（ＣＲ）１例，部分缓解（ＰＲ）１６例，稳定（ＮＣ）４例，恶化（ＰＤ）２例。８例咯血治疗后，６例消失，２例减轻为痰血。６例胸痛治疗后，３例完全消失，１例明显好转，２例无变化。６例阻塞性肺不张治疗后，２例肺复张，１例明显好转，３例无变化。影像学改变：肿块缩小，密度增加或伴空洞形成。组织学变化：肿瘤组织液化坏死，癌细胞变性，不同程度纤维化增生。毒副反应及并发症轻，无严重不良反应。结论本法全身毒副反应轻，抗肿瘤效果显著，症状缓解率高。
Objective To observe the efficacy of X-ray guided interventional chemotherapy for lung cancer. Methods X-ray guided lung perfusion chemotherapy was performed in 23 patients with advanced lung cancer. There were 21 cases of non-small cell lung cancer and 2 cases of small cell lung cancer. There were 17 cases in stage III and 6 cases in stage IV. The drug is pirarubicin (THP) 40 ~ 60mg/m2, vincristine 2mg and carboplatin 400mg/m2, diluted to 10 ~ 20ml, once every 3 weeks, three times for a course of treatment, a total of 95 cases. Results There were 1 case of complete remission (CR), 16 cases of partial remission (PR), 4 cases of stable (NC), and 2 cases of worsening (PD). After treatment with hemoptysis in 8 cases, 6 cases disappeared, and 2 cases reduced to hemorrhage. After 6 cases of chest pain treatment, 3 cases completely disappeared, 1 case significantly improved, 2 cases did not change. After treatment of obstructive pulmonary atelectasis in 6 patients, 2 patients had reexpansion of lung, 1 patient improved significantly, and 3 patients had no change. Imaging changes: shrinking masses, increased density, or cavitation. Histological changes: tumor tissue liquefaction and necrosis, cancer cell degeneration, varying degrees of fibroplasia. The toxic side effects and complications were light, and there were no serious adverse reactions. Conclusions This method has less toxicity and anti-tumor effects, and has a high symptom remission rate.