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目的探讨家蝇蛆粉对大鼠的致畸性,以评价其安全性。方法家蝇蛆粉按比例定量添加到普通饲料原料中混匀,干燥,做成高、中、低剂量家蝇蛆粉饲料。将性成熟的98只SD大鼠按雌雄2:1的比例同笼交配。取64只孕鼠平均分为四组:家蝇蛆粉饲料低剂量组;家蝇蛆粉饲料中剂量组;家蝇蛆粉饲料高剂量组;普通饲料对照组。于受孕后称量体重增长情况。最后脱颈椎处死孕鼠,称子宫重量,并进行胎鼠检查。结果家蝇蛆粉饲料高、中、低剂量组与对照组相比,雌鼠体重增长未见显著差异,子宫重量未见显著差异,无吸收胎、早死胎、晚死胎;各组间雄性与雌性胎鼠数均未见显著差异;各组间雄性与雌性胎鼠的外观、体重、体长均未见显著差异。各组间胎鼠骨骼和胎鼠内脏均未见显著差异。结论家蝇蛆粉对SD大鼠未见致畸性。
Objective To investigate the teratogenicity of housefly maggot powder in rats to evaluate its safety. Methods Musca domestica maggot quantitatively added to the normal feed ingredients in a quantitative manner, mixing, drying, made of high, medium and low doses of housefly maggot powder feed. The sexual maturity of 98 SD rats according to male and female ratio of 2: 1 with the cage mating. Sixty-four pregnant rats were equally divided into four groups: low-dose group of housefly maggot powder feed; medium-dose group of housefly maggot powder feed; high-dose group of housefly maggot powder feed; normal feed control group. Weigh the weight gain after conception. Finally, cervical offspring dead rats, said the weight of the uterus, and fetal examination. Results There was no significant difference in body weight gain between the high, medium and low dose groups of housefly maggot powder diet and the control group, no significant difference in the weight of the uterus between the two groups There was no significant difference in the number of female fetuses; there was no significant difference in appearance, body weight and body length between male and female fetuses in each group. There was no significant difference in fetal rat skeletal and fetal rat internal organs between groups. Conclusion Musca domestica did not induce teratogenicity in SD rats.